Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance
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چکیده
منابع مشابه
Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor.
Candida glabrata has emerged as a common cause of fungal infection. This yeast has intrinsically low susceptibility to azole antifungals such as fluconazole, and mutation to frank azole resistance during treatment has been documented. Potential resistance mechanisms include changes in expression or sequence of ERG11 encoding the azole target. Alternatively, resistance could result from upregula...
متن کاملazole-resistant Candida glabrata
Case report-Subjects-Three cases are described oflong-standing vaginal candidosis due to Candida glabrata. These had failed to respond to local and systemic antifungals. In each case the infecting strain appeared resistant to a range of azole drugs in vitro. Clinical course-Case one-This patient recovered following prolonged treatment with oral itraconazole in combination with oral and vaginal ...
متن کاملMechanisms of azole resistance in petite mutants of Candida glabrata.
We previously showed that resistant colonies of Candida glabrata inside the azole inhibition zones had respiratory deficiency due to mutations in mitochondrial DNA. Here, we analyzed the mechanisms of azole resistance in petite mutants of C. glabrata obtained by exposure to fluconazole or induced by ethidium bromide. The respiratory deficiency of these mutants was confirmed by oxygraphy and flo...
متن کاملCandida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants.
Candida glabrata, a yeast with intrinsically low susceptibility to azoles, frequently develops increased azole resistance during prolonged treatment. Transposon mutagenesis revealed that disruption of CgPDR1 resulted in an 8- to 16-fold increase in fluconazole susceptibility of C. glabrata. CgPDR1 is a homolog of Saccharomyces cerevisiae PDR1, which encodes a transcriptional regulator of multid...
متن کاملFlucytosine antagonism of azole activity versus Candida glabrata : 3 Role of transcription
9 10 Department of Microbiology and Immunology, Drexel University College of Medicine, 11 Philadelphia, Pennsylvania, 1 and Femeris Women’s Health Research Center, Medical Diagnostic 12 Laboratories, Hamilton, New Jersey 2 13 14 15 Running title: FLUCYTOSINE-AZOLE ANTAGONISM IN CANDIDA GLABRATA 16 17 18 * Corresponding author. Mailing address: Department of Microbiology and Immunology, Drexel 1...
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ژورنال
عنوان ژورنال: Current Genetics
سال: 2018
ISSN: 0172-8083,1432-0983
DOI: 10.1007/s00294-018-0870-4